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Research 03 · Under review · SN Computer Science

Medical Image Retrieval

A medical image search system that knows when to say “I don’t know” and hands the case to a clinician.

My role
Co-author
Status
Under review · SN Computer Science · 2026
Data
PathMNIST (histopathology), with zero-shot cross-domain tests
Authors
Prasun Nandy, Akshat Singhania, Rik Das, Aaditya Dev Sharma, Agneesh Raychaudhuri, Saranik Mahapatra
0.957mAP@20 with attention fusion, cross-seed σ of just 0.0014
0.964mAP@20 after PPO-learned distance weighting
0.987mAP@20 when the least confident half is deferred to experts

Content-based image retrieval can support diagnosis by surfacing similar past cases. But a single network architecture captures only part of what medical images look like, and standard networks return confidently wrong answers on ambiguous inputs.

The design principle: in a clinic, withholding a recommendation is far safer than giving a wrong one.

  1. 01Three backbones

    EfficientNet-B0, ViT-Tiny and SE-ResNet34 encode complementary features.

  2. 02Cross-modal attention fusion

    Multi-head self-attention makes the backbones cross-reference each other.

  3. 03PPO distance weighting

    A reinforcement-learning agent tunes fusion weights per query.

  4. 04Monte Carlo dropout + BALD

    Estimates epistemic uncertainty for every query.

  5. 05Defer to a clinician

    Uncertain queries go to a human instead of getting a forced answer.

mAP@20 as each stage is added

Values are close together, so the axis starts at 0.95. Deferral trades coverage for precision.

Naive fusion is unstable

Concatenating or averaging backbone features is highly sensitive to the random seed. Attention fusion brings cross-seed variance down to 0.0014.

The RL layer is scoped honestly

The PPO agent is a dataset-specific optimizer that must be retrained per corpus, not a zero-shot generaliser, and the paper says so.

Uncertainty doubles as an intruder alert

Epistemic uncertainty rises by about 60% on out-of-distribution inputs, so unfamiliar or random images are caught and deferred.

The most useful thing a clinical model can do is know its limits. Precision climbs steadily as the system is allowed to defer.

Full titleContent-Based Medical Image Retrieval through Cross-Modal Attention Fusion, Reinforcement-Learned Distance Weighting, and Monte Carlo Uncertainty Estimation

PyTorchVision TransformersReinforcement learningBayesian uncertaintyMedical imaging
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